At around 17:45 Beijing time on October 5, 2022, the 2022 Nobel Prize in Chemistry was awarded to American scholar Caroline R. Bertosi, Danish scholar Morten Medal, and American scholar K Barry Shapley, in recognition of their contributions to the development of click chemistry and bioorthogonal chemistry.

Carolyn R. Bertozzi was born in 1966 in the United States. I obtained my doctoral degree from the University of California, Berkeley in 1993. Current professors Anne T. and Robert M. Bass at Stanford University in the United States.

Morten Meldal was born in Denmark in 1954. Obtained a doctoral degree from the Technical University of Denmark in 1986. Current professor at the University of Copenhagen in Denmark.

K. K. Barry Sharpless was born in Philadelphia, Pennsylvania, USA in 1941. Obtained a doctoral degree from Stanford University in the United States in 1968. Current Professor W. M. Keck at the Scripps Research Center in the United States. He shared the 2001 Nobel Prize in Chemistry with two other scholars for his research on chiral catalytic oxidation reactions. This award makes him the second scientist, after Frederick Sanger, the pioneer of protein sequencing and DNA sequencing, to receive the Nobel Prize in Chemistry twice.

Sometimes a simple answer is the best. Barry Shapley and Morten Medal brought chemistry into the functionalist era and laid the foundation for click chemistry; They are with Caroline R Bertosi shared the 2022 Nobel Prize in Chemistry, which took click chemistry to a whole new dimension and began using this tool to draw cell maps. The bioorthogonal reaction developed by Bertosi has achieved various applications, including promoting the development of more targeted cancer therapies.

Since the birth of modern chemistry in the 18th century, many chemists have used nature as a model for their research. Life itself is the best proof of nature's supreme ability to create chemical complexity. The astonishing molecular structures discovered in plants, microorganisms, and animals have prompted researchers to attempt to construct identical molecules through artificial synthesis. In drug development, imitating natural molecules is often an important part, as many drugs are inspired by natural substances.

The chemical knowledge accumulated over centuries has proven its value. Using the complex tools developed, chemists can now create a variety of extremely amazing molecules in the laboratory. However, a challenging problem is that complex molecules must be constructed through many steps, each of which produces unwanted byproducts - sometimes more, sometimes less. In order to obtain the desired compounds, these by-products must be removed before continuing with the subsequent reaction process. For chemical structures that are difficult to synthesize, the loss of raw materials may be significant, and the products after the reaction are almost zero. Chemists often achieve challenging goals, but the routes they use can be both time-consuming and expensive. The 2022 Nobel Prize in Chemistry is about finding new and ideal chemistry, prioritizing simplicity and functionality.